A robust approach to estimating rates from time-correlation functions
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John D. Chodera, Phillip J. Elms, William C. Swope, Jan-Hendrik Prinz, Susan Marqusee, Carlos Bustamante, Frank Noé, Vijay S. Pande
Preprint ahead of submission: [arXiv] [PDF] [SI]
The estimation of rates from experimental single-molecule data is fraught with peril. We describe some of the failures of existing methods and suggest a robust way to estimate rates from time-correlation functions.