A novel small-molecule pan-Id antagonist inhibits pathologic ocular neovascularization

agx51.png

Paulina M. Wojnarowicz, Raquel Lima e Silva, Masayuki Ohanka, Sang Bae Lee, Yvette Chin, Anita Kulukian, Sung-Hee Chang, Bina Desai, Marta Garcia Escolano, Riddhi Shah, Marta Garcia-Cao, Sijia Xu, Rashmi Thakar, Yehuda Goldgur, Meredith A. Miller, Ouathek Ouerfelli, Guangli Yang, Tsutomu Arakawa, Steven K. Albanese, William A. Garland, Glenn Stoller, Jaideep Chaudhary, Rajesh Soni, John Philip, Ronald C. Hendrickson, Antonio Iavarone, Andrew J. Dannenberg, John D. Chodera, Nikola Pavletich, Anna Lasorella, Peter A. Campochiaro, and Robert Benezra
Submitted.

We report the discovery and characterization of a small molecule, AGX51, with the surprising ability to inhibit the interaction of Id1 with E47, which leads to ubiquitin-mediated degradation of Ids.

Overview of the SAMPL6 host-guest binding affinity prediction challenge

Andrea RizziSteven MurkliJohn N. McNeillWei YaoMatthew SullivanMichael K. Gilson, Michael W. Chiu, Lyle IsaacsBruce C. GibbDavid L. Mobley*, John D. Chodera*
* denotes co-corresponding authors
Journal of Computer-Aided Molecular Design special issue on SAMPL6, 32:937, 2018. [DOI] [bioRxiv] [GitHub]

We present an overview of the host-guest systems and participant performance for the SAMPL6 host-guest blind affinity prediction challenges, assessing how well various physical modeling approaches were able to predict ligand binding affinities for simple ligand recognition problems where receptor sampling and protonation state effects are eliminated due to the simplicity of supramolecular hosts. We find that progress is now stagnated likely due to force field limitations.