Bayesian analysis of isothermal titration calorimetry for binding thermodynamics

Trung Hai Nguyen, Arien S. Rustenburg, Stefan G. Krimmer, Hexi Zhang, John D. Clark, Paul A. Novick, Kim Branson, Vijay S. Pande, John D Chodera, David D. L. Minh.
PLoS One, in press. [bioRxiv]

We show how Bayesian inference can produce greatly improved estimates of statistical uncertainty from isothermal titration calorimetry (ITC) experiments, allowing the joint distribution of thermodynamic parameter uncertainties to be inferred.