L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
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Intlekofer A, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, and Thompson CB.
Nature Chemical Biology 13:494, 2017. [DOI] [PDF] [GitHub]
At low pH, metabolic enzymes lactate dehydrogenase and malate dehydrogenase undergo shifts in substrate utilization that have high relevance to cancer metabolism due to surprisingly simple protonation state effects.
